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This tells us the medication's therapeutic window is robustadherence and dose escalation matter far more than circadian timing
The medications have surged in popularity in recent years, but not all the attention has been positive
RCT conducted in patients with T2D showed that high doses of tirzepatide represent the most efficacious incretin-based anti-diabetes drug in terms of BW reduction 33 , sustaining the development of the SURMOUNT program to explore its efficacy and safety in the management of obesity 9
These mechanisms improve glucose metabolism, hormonal balance, and inflammation and reduce insulin resistance
But there is a problem, and if Im honest, something that makes these drugs less miraculous: They stop working when you stop taking them
GLP-1 functions to delay gastric emptying, stimulate insulin secretion and mediate satiety in the central nervous system (CNS), all actions that are beneficial to individuals with obesity and type 2 diabetes
